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美丽女子金秀炫（李宝英饰）堪称是所有女人羡慕和嫉妒的对象，她拥有完美的家庭，丈夫韩志勋（金泰佑饰）从事律师行业，受人尊敬，女儿小星（金柳彬饰）乖巧可爱，调皮伶俐。职场上秀炫又是一名小有名气的时事节目作家，可以说她的人生完美得连命运之神都会嫌忌。终于在某一天，巨大的变故砸向这个梦幻般的家庭。小星意外遭人绑架，几经周折后更被抛尸湖中。绝望的秀炫跳入湖中，似乎此时她又受到神明的眷顾，竟然由此穿越时空回到了女儿被杀的两周前。提前知晓了悲剧命运的秀炫，绝不肯轻易放弃这个改写自己和女儿人生的最后良机，她和死神展开了争分夺秒的赛跑……
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Dr Lucinda Edwards (Niamh Algar) is a smart, battle-hardened doctor, but we meet her on a nightmare shift that ends in the death of an opioid overdose victim, Edith Owusu. Despite the support of her medical supervisor, Dr Leo Harris, played by James Purefoy (A Discovery of Witches, Pennyworth, Sex Education), Edith's grieving father Sir Anthony Owusu, played by Brian Bovell (Crime, Strike), demands an enquiry into Lucinda's actions on the fateful night. Leading the medical investigation are Dr Norma Callahan played by Helen Behan (Holding, The Virtues) and Lucinda's former colleague, Dr George Adjei, played by Jordan Kouamé (Megalomania). While George feels this was an unavoidable tragedy, Norma is suspicious of Lucinda's behaviour and decisions in the lead up to Edith's death. As the pressure of the investigation intensifies, Lucinda's relationship with husband Tom, played by Lorne MacFadyen (Pistol, Vigil) starts to fracture, and her confident professional exterior begins to crack. Is Lucinda hiding something? Through the cat and mouse thriller of the medical investigation, Malpractice tells the story of a damaged doctor caught up in a dangerous conspiracy.